VMRD, Inc. - Antibodies

CD8β

Catalog No. HT14A

Ig Class IgG1

Applications: Flow cytometry, immunohistochemistry, cell function.

% Labeled PBMC: 13

Species Activity:

Cattle	Goat	Sheep	Swine	Horse	Cat	Dog	Ferret	Mink	Human	Mouse	Rabbit
-	-	-	-	+	-	-	-	-	-	NT	NT

FACS Profile:

FACS profile above obtained with equine leukocytes.
CD8 is expressed on most thymocytes and approximately 1/3rd of peripheral blood T cells in humans. CD8 alpha/beta heterodimers are expressed only on TCR alpha/beta T cells whereas CD8 alpha homodimers can be expressed on alpha beta and gamma delta T cells and some NK cells in humans. The pattern of expression in other species has not been well documented.

This monoclonal antibody is produced as mouse ascites fluid, clarified by centrifugation, and filtered through a 0.2 micrometer filter. The antibody concentration is 1.0 mg/ml in phosphate-buffered saline, preserved with 0.09% sodium azide.

Flow Cytometry Procedure • IHC Procedure • FAQ's

References

Certificate of Analysis
Furr, M.O., et al. Immunodeficiency associated with lymphosarcoma in a horse. J. Am. Vet. Med. Assoc. 201(2):307-309 (July 1992).
Kydd, J., et al. Report of the First International Workshop on Equine Leucocyte Antigens, Cambridge, UK, July 1991. Vet. Immunol. Immunopathol. 42(1):3-60 (July 1994).
Bilzer, T., et al. Presence of CD4+ and CD8+ T cells and expression of MHC class I and MHC class II antigen in horses with Borna disease virus-induced encephalitis. Brain Pathology 5(3):223-230 (July 1995).
Brostrom, H., et al. Generation of in vitro natural cytotoxicity of horse lymphocytes against sarcoid-derived tumor cells not expressing major histocompatibility complex antigens. Am. J. Vet. Res. 57(7):992-999 (July 1996).
Tschetter, J.R., et al. CD8 dimer usage on alpha beta and gamma delta T lymphocytes from equine lymphoid tissues. Immunobiol. 198(4):424-438 (Feb. 1998).
Tunon, A.M., et al. Influence of age and parity on the distribution of cells expressing major histocompatibility complex class II, CD4, or CD8 molecules in the endometrium of mares during estrus. Am. J. Vet. Res. 60(12):1531-1535 (Dec. 1999).

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